CD27 anticorps

N° du produit ABIN5707991

Cet anticorps Lapin Monoclonal détecte spécifiquement CD27 dans IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour CD27 anticorps (ABIN5707991)

Antigène: CD27 (CD27 Molecule (CD27))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD27 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CDLA27-1R

Détail du produit anti-CD27 anticorps

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: Human CD27 protein was used as the immunogen for the recombinant CD27 antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the recombinant CD27 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant CD27 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD27

Antigène: CD27 (CD27 Molecule (CD27))

Autre désignation: CD27

Sujet: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. CD27 transduces signals that lead to the activation of NF-kB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [Wiki]

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints